This study was planned to evaluate the clinical and histopathological status of the ovarian malignant germ cell tumor, which was made on a series of 19 cases with ovarian malignant germ cell tumor, who were admitted, operated and confirmed with
postoperative histopathological study at department of obstetrics and gynecology, Yonsei University Wonju Christian Hospital, during the period of 10 years from 1984 Jan. to 1993 Dec.
@ES The results obtained were as follows:
@ES 1. The incidence of malignant germ cell tumor among 691 cases of ovarian tumor and 141 cases of germ cell tumor were 2.7%(19/691) and 13.5%(19/141).
2. Among malignant germ cell tumors by histopathological classification, dysgerminoma was most frequently reveal in 8 cases(42.1%0, immature teratoma in 6 cases(31.6%), mixed germ cell tumor in 3 cases (15.8%), endodermal sinus tumor in 1
case(5.3%),
embryonal carcinoma in 1 cases(5.3%).
3. Age distribution revealed between 8 and 31 years old, mean age was 17.4 years old, most frequently revealed in teenager.
4. According to FIGO classification, the patients were classified as; Stage I 84.2%, Stage III 5.3%, Stage IV 10.5%.
5. According to tumor markers, α-FP was increased in mixed germ cell cumor, β-HCG in mixed germ cell tumor and dysgerminoma, CEA in immature teratoma, CA-125 in immature teratoma.
6. Six of 19 cases who were treated with multiple agent combination chemotherapy (VAC) underwent second-look procedure, and 2 cases have developed recurrence, 4 cases have completely remission.
7. Two cases have did who have endodermal sinus tumor and mixed germ cell tumor, and interval to death was 32 month and 28 month.
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